ZNF521 promotes acute myeloid leukemogenesis by suppressing the expression and acetylation of SMC3
Zinc finger protein 521 (ZNF521) participates in the self-renewal of hematopoietic stem cells, and its abnormal expression has been implicated to promote leukemia.However, the specific role of ZNF521 in leukemia has not been fully understood.In this study, we aimed to further elucidate its role.Using acute leukemia cell line THP-1, we demonstrated